Boone County Health Alert. Mouth Bacteria Linked to Colorectal Cancer Growth. Doctor Explains

Cover Image: Boone County Health Alert. Mouth Bacteria Linked to Colorectal Cancer Growth. Doctor Explains

Recent research has identified that a subtype of Fusobacterium nucleatum is linked to nearly half of human colorectal cancers. This significantly advances our understanding of how microbes influence cancer development.

The Big Picture: Dr. Puja Uppal, Family Medicine, "...specifically, the Fna C2 type, which infiltrates tumors, has distinct genetic characteristics that allow it to travel from the mouth to the gut..."

Doctor's Expert Insights about Rising Colon Cancer Rates in Indiana

Know this: "You should know that the incidence of colon cancer in younger people is rising dramatically. Researchers at Fred Hutchinson Cancer Center have identified a specific subtype of Fusobacterium nucleatum, a bacterium usually found in the mouth, that contributes to the growth of colorectal cancer tumors in the gut.

Due to the rising incidence of colon cancer, recent updates to screening guidelines by the US Preventive Services Task Force (USPSTF) and the American Cancer Society now advise that all residents Indiana aged 45 and older should undergo a colon cancer screening.

Also, individuals with a 'first-degree' relative who has or had colon cancer are considered at increased risk and should consider earlier screening. It's important to discuss your specific situation with your healthcare provider. (Read More Here)

Next steps: Talk to your doctor and get your colonoscopy! Most insurances in Boone County, Indiana will cover the screening colonoscopy." Dr. Shelandra Bell, Family Medicine.

Health News Today: A specific type of bacteria in the mouth has been linked to many colorectal cancers.

Key Findings for you in for Boone County, Indiana

Findings from the Study:

A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche: The study found that a specific group of Fusobacterium nucleatum subspecies animalis (Fna), called Fna clade 2 (Fna C2), is enriched in colorectal cancer tumors compared to Fna clade 1 (Fna C1).

Key point: Fna C2 is dominant in colorectal cancers.

Fna C2 has distinct genetic and epigenetic features compared to Fna C1: Comparative genomic and epigenetic analyses revealed that Fna C2 has additional accessory genes and DNA methylation patterns that distinguish it from Fna C1. The two clades of Fna have evolved distinct genomic and epigenetic characteristics that likely contribute to their differing abilities to colonize the colorectal cancer niche.

Fna C2 shows increased metabolic potential and gastrointestinal tract colonization: Fna C2 contains 195 clade-associated genetic factors consistent with enhanced nutrient scavenging and metabolic capabilities that may facilitate gastrointestinal tract transit and colorectal tumor colonization compared to Fna C1

Essentially, specific genes in Fna C2 appear to provide it with metabolic advantages that allow it to survive passage through the gastrointestinal tract and thrive in the tumor microenvironment.

Fna C2 has a stronger association with colorectal cancer than Fna C1 in stool metagenomes: Meta-analysis of stool metagenomic data from colorectal cancer patients and healthy controls found both Fna clades were associated with colorectal cancer, but Fna C2 had a larger effect size and was more prevalent.

Key point: Even in stool samples, the presence and abundance of Fna C2 appears to be a stronger indicator of colorectal cancer than Fna C1, though both are associated with the disease state.

Medical News Today: Key Takeaway for You in Boone County, Indiana

The identification of a Fusobacterium nucleatum subtype implicated in a significant portion of colorectal cancers is an important step forward in the battle against colorectal cancer. In time, this could be a promising new direction for screening and treatment of this deadly disease.

Keep in mind, that more and more younger people are being afflicted with colon cancer.

"We’ve consistently seen that patients with colorectal tumors containing Fusobacterium nucleatum have poor survival and poorer prognosis compared with patients without the microbe..." Susan Bullman, PhD. (Study Editorial)

What They're Saying: "Fn, a member of the oral microbiota, has gained attention as an emerging cancer-associated bacterium. Worldwide, unbiased genomic analyses have revealed an enrichment of Fn in human CRC relative to non-cancerous colorectal tissues 9. Previous work by our group and others demonstrated that patients with CRC tumours harbouring high levels of Fn have poorer survival5, that Fusobacterium colonizes regions of patient tumours with immune and epithelial cell functions supportive of cancer progression 10, that Fusobacterium persists in metastatic disease 6 and that microbiome modulation targeting Fn could change the course of this disease 6,11. " (Study Source)

Health Standard Newswire: Processed foods are being speculated as one of the key factors for the rise in colon cancer in younger people.

Medical News and Statistics for Boone County, Indiana

The following health facts impact your physical health directly!

Did you know there were 13983 deaths from Cancer in Indiana in 2021?

34.8% of you in Boone County are obese.

21.6% of you in Boone County have depression.

14.3% of you in Boone County are smokers.

All of these variables above play an important role in the outcomes of your overall health.

The Health Standard Newswire.